| 中文名称: | SB 431542 hydrate 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | SB 431542 hydrate | ||||
| 别名: | 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate | ||||
| CAS No: | 301836-41-9 | 分子式: | C22H16N4O3.XH2O | 分子量: | 384.39 |
| CAS No: | 301836-41-9 | ||||
| 分子式: | C22H16N4O3.XH2O | ||||
| 分子量: | 384.39 | ||||
| MDL: | MFCD05865244 | ||||
一种转化生长因子 β 受体 (TGF-β Receptor) 抑制剂和有效的ALK5 抑制剂,TGFβ RII: IC50 = 66 nM (human); TGFβ RI: IC50 = 94 nM; ACTR-IB: IC50 = 140 nM。
SB 431542 is a small molecule that acts as a specific and selective inhibitor of TGFβ RI, ACTR-IB and ACTR-IC (transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, 5, and 7). Renal carcinoma studies have demonstrated that SB 431542 is a selective inhibitor of Smad3 phosphorylation (IC50= 94nM) and TGF-β-1 collagen induced lα1 (col Iα1). It has been reported that SB 431542 does not affect the JNK, ERK, or p38 MAP kinase pathways. SB 431542 has been shown to suppress TGF-β induced growth stimulation in MG63 cells, inhibit the motility and proliferation of glioma cells, and block the phosphorylation and translocation of SMADs.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
