| 中文名称: | SU9516 | ||||
|---|---|---|---|---|---|
| 英文名称: | SU9516 | ||||
| 别名: | (Z)-3-((1H-imidazol-5-yl)methylene)-5-methoxyindolin-2-one | ||||
| CAS No: | 666837-93-0 | 分子式: | C13H11N3O2 | 分子量: | 241.25 |
| CAS No: | 666837-93-0 | ||||
| 分子式: | C13H11N3O2 | ||||
| 分子量: | 241.25 | ||||
一种强力的有选择性的周期蛋白依赖性激酶（CDKs）抑制剂。
SU9516 is a 3-substituted indolinone compound displaying anti-proliferative and proapoptotic properties in tumor cells. SU9516 displays activity as a selectively potent ATP-competitive inhibitor of CDKs. It also shows no significant effect (IC50 >10 μM) on the activities of PKC, p38, PDGFRβ, or EGFR. SU9516 has an Inhibitory effect on proliferation of growth-factor stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F. SU9516 is an inhibitor of Cdc2, Cdk2 and Cdk4.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
