| 中文名称: | MDK-1699 | ||||
|---|---|---|---|---|---|
| 英文名称: | MDK-1699 | ||||
| 别名: | 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid SKPin C1 | ||||
| CAS No: | 432001-69-9 | 分子式: | C18H13BrN2O4S2 | 分子量: | 465.34 |
| CAS No: | 432001-69-9 | ||||
| 分子式: | C18H13BrN2O4S2 | ||||
| 分子量: | 465.34 | ||||
一种抑制Skp2介导的p27降解的抑制剂.
MDK-1699 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. IC50 value: Target: Skp2 inhibitor; p27 regulator in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1and correlates with increased p27 protein levels .
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
