| 中文名称: | GW4869 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | GW4869 | ||||
| 别名: | N,N′-Bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3,3′-p-phenylene-bis-acrylamide dihydrochloride N,N′-Bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3,3′-p-phenylene-bis-acrylamide dihydrochloride | ||||
| CAS No: | 6823-69-4 | 分子式: | C30H28N6O2.2HCl | 分子量: | 577.5 |
| CAS No: | 6823-69-4 | ||||
| 分子式: | C30H28N6O2.2HCl | ||||
| 分子量: | 577.5 | ||||
一种非竞争性的中性鞘磷脂酶（Smase)抑制剂,IC50为1 μM.
GW4869 (dihydrochloride hydrate) is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). GW4869 functions as an inhibitor, via a non-competitve manner. N-SMases are important in the metabolism of sphingomyelin producing ceramide and phosphocholine, which are important in cell signaling and regulation. Studies indicate that GW4869 can inhibit the activation of N-SMase by TNF-α in MC7 cells. As a result of this inhibition cell death and growth suppression are inhibited. Although GW4869 does not effect polymorphonuclear neutrophil (PMN) motility, it is useful with formylmethionylleucylphenylanaline (FMLP), since it inhibits PMN aggregation towards the chemotaxin.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
