| 中文名称: | BQCA | ||||
|---|---|---|---|---|---|
| 英文名称: | BQCA | ||||
| 别名: | 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Benzyl quinolone carboxylic acid | ||||
| CAS No: | 338747-41-4 | 分子式: | C18H15NO4 | 分子量: | 309.32 |
| CAS No: | 338747-41-4 | ||||
| 分子式: | C18H15NO4 | ||||
| 分子量: | 309.32 | ||||
| MDL: | MFCD01315710 | ||||
包装规格：
5mg 25mg 100mg in glass bottle
产品简介：
一种有效的毒蕈碱M1受体（MACHR阳性变构调节剂。
溶解性：
溶于DMSO(10mg/ml)
储备液保存：
-80°C, 2 years
-20°C, 1 year
-20°C, 1 year
体外研究：
BQCA reduces the concentration of ACh required to activate M1 up to 129-fold with an inflection point value of 845 nM. No potentiation, agonism, or antagonism activity on other mAChRs is observed up to 100 μM. BQCA increases M1 receptor affinity for acetylcholine. The activation of the M1 receptor by BQCA induces a robust inward current and increases spontaneous excitatory postsynaptic currents in medial prefrontal cortex (mPFC) pyramidal cells.
体内研究：
BQCA requires M1 to promote inositol phosphate turnover in primary neurons and to increase c-fos and arc RNA expression and ERK phosphorylation in the brain. BQCA reverses scopolamine-induced memory deficits in contextual fear conditioning, increases blood flow to the cerebral cortex, and increases wakefulness while reducing delta sleep. BQCA induces β-arrestin recruitment to M1, suggesting a role for this signal transduction mechanism in the cholinergic modulation of memory. BQCA increases firing of mPFC pyramidal cells in vivo. BQCA also restores discrimination reversal learning in a transgenic mouse model of Alzheimer's disease.
保存条件：
-20℃
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
UN码：
HazardClass：
危害声明：
安全说明：
搜索质检报告(COA)
参考文献 & 客户发表文献
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质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
