| 中文名称: | ASP7663 | ||||
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| 英文名称: | ASP 7663 | ||||
| 别名: | (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid | ||||
| CAS No: | 1190217-35-6 | 分子式: | C14H14FNO3 | 分子量: | 263.26 |
| CAS No: | 1190217-35-6 | ||||
| 分子式: | C14H14FNO3 | ||||
| 分子量: | 263.26 | ||||
基本信息
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产品编号： |
A10077 |
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产品名称： |
ASP 7663 |
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CAS: |
1190217-35-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
两年 |
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分子量 |
263.26 |
-20℃ |
一个月 |
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化学名： |
(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid |
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Solubility (25°C)： |
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体外:
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DMSO |
53mg/mL |
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Ethanol |
30mg/mL |
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Water |
Insoluble |
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体内(现配现用): |
1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.08mg/mL (7.90mM); Clear solution |
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此⽅案可获得 ≥ 2.08mg/mL (7.90mM，饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例，取 100μL 20.8mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。 |
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2.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.08mg/mL (7.90mM); Clear solution |
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此⽅案可获得 ≥ 2.08mg/mL (7.90mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 20.8mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。 |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.7985mL |
18.9926mL |
37.9853mL |
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5mM |
0.7597mL |
3.7985mL |
7.5971mL |
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10mM |
0.3799mL |
1.8993mL |
3.7985mL |
生物活性
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产品描述 |
一种选择性的TRAP1激活剂，人、大鼠和小鼠的EC50值分别为510nm, 540nm和500nm。 |
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靶点 |
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体外研究 |
ASP7663 concentration dependently increases intracellular Ca2+ concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC50 values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63)μmol/L. ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9)μmol/L |
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体内研究 |
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice. ASP7663 (orally, 0.3 and 1mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide. ASP7663 (orally, 1 and 3mg/kg) exhibits inhibitory effects on colorectal distension in rat |
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Animal Model: |
CRD model (colorectal distension in rat). |
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Dosage: |
1 and 3mg/kg. |
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Administration: |
Orally. |
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Result: |
Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60mMHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
